New Research Suggests SANGUINATE™ Reduces the Number of Sickled Red Blood Cells in Patients with Vaso-Occlusive Crisis
Restoration of Normal Morphology May Reduce Opiate Use and Prevent Hospitalization
SOUTH PLAINFIELD, N.J., May 1, 2017 – SANGUINATE™, the only investigational biopharmaceutical product currently in clinical development for the treatment of multiple comorbidities of sickle cell disease (SCD), is effective in returning red blood cells to a more normal morphology (shape) in patients experiencing vaso-occlusive crisis (VOC) related to SCD, according to research presented at the 11th Annual Symposium of the Foundation for Sickle Cell Disease Research (FSCDR) in Fort Lauderdale, Fla.
Sickle cell disease is a group of chronic genetic disorders that affects an estimated 70,000 to 80,000 Americans.1 Vaso-occlusive crisis, the most common complication of SCD, is an extremely painful, potentially deadly condition characterized by abnormal hemoglobin, a protein in red blood cells that transports oxygen from the lungs to tissues and organs in the body and carries carbon dioxide back to the lungs. 2,3 Cells affected by VOC become sickle- or crescentshaped, a deformity that prevents them from flowing freely through blood vessels, potentially causing excruciating pain and other symptoms that may lead to death. 4 VOC results in approximately 197,000 emergency department visits each year in the U.S. and costs an estimated $356 million annually for pain management alone.5
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1Genetics Home Reference. Sickle cell disease. 2016. https://ghr.nlm.nih.gov/condition/sickle-cell-disease#diagnosis.
2National Institutes of Health, National Heart, Lung, and Blood Institute. Evidence-based management of sickle cell disease. Expert panel report. 2014. http://www.nhlbi.nih.gov/health-pro/guidelines/sickle-cell-disease-guidelines.
3National Institutes of Health, National Cancer Institute. NCI Dictionary of Cancer Terms. 2017. https://www.cancer.gov/publications/dictionaries/cancer-terms?cdrid=45108.
4National Institutes of Health, National Heart, Lung, and Blood Institute. What is sickle cell disease? 2016. http://www.nhlbi.nih.gov/health/health-topics/topics/sca.
5Wilson BH, Nelson J. Sickle cell disease pain management in adolescents: a literature review. Pain Manag Nurs. 2015;16(2):146–151.
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